TARIS® IS BUILDING A UNIQUE THERAPEUTICALLY-FOCUSED UROLOGY COMPANY DEVELOPING POWERFUL AND TARGETED NEW TREATMENTS FOR MILLIONS OF PATIENTS SUFFERING FROM DIFFICULT-TO-TREAT BLADDER DISEASES.
TARIS® WAS FOUNDED TO ADDRESS A LONG STANDING CLINICAL NEED FOR IMPROVED TREATMENTS FOR DEBILITATING BLADDER CONDITIONS.
TARIS Biomedical® was founded in 2008 in response to a long-standing clinical need for a convenient, safe, and effective way to treat bladder disease locally. Encouraged by the effectiveness of local bladder instillations but frustrated by the need for frequent repeated dosing due to normal bladder emptying, urologists expressed a desire for a better approach. TARIS®’s solution is a brilliantly simple and elegant system that can continuously deliver drug in the bladder. It was conceived in the laboratories of internationally renowned biotechnology entrepreneurs Robert Langer and Michael Cima at the Massachusetts Institute of Technology. Since its inception, TARIS® has applied this technology in the development of products with a potential to provide effective and well-tolerated therapeutics for difficult-to-treat urological conditions. TARIS®’s first program, LiRIS® (lidocaine releasing intravesical system), for the treatment of interstitial cystitis/bladder pain syndrome was acquired by Allergan®, in August of 2014. This sale was an important validation of our approach; TARIS® has now turned its focus to developing a broad portfolio of products addressing significant unmet need in the treatment of several debilitating bladder diseases, including bladder cancer and overactive bladder.
PURNANAND D. SARMA, Ph.D.
President and Chief Executive Officer
Dr. Sarma comes to TARIS® with more than 20 years of pharmaceutical experience in large, medium and small companies. Most recently, he was General Manager and Vice President of Worldwide Drug Delivery Technologies of CIMA LABS, Inc., a wholly owned subsidiary of Cephalon (now Teva). Prior to Cephalon, Dr. Sarma served as Vice President of Pharmaceutical Development at Nektar Therapeutics (NASDAQ:NKTR), based in the San Francisco Bay area. Dr. Sarma started his career at SmithKline Beecham Pharmaceuticals, in the areas of formulation sciences and product development. He earned a BS in Pharmacy from Andhra University in Visakhapatnam, India and a Ph.D. in Pharmaceutics from the University of Minnesota.
CHRISTOPHER J. CUTIE, M.D., MBA
Chief Medical Officer
Dr. Cutie joins TARIS® with more than 10 years of clinical experience as a practicing urologist. Most recently, he was Instructor in Surgery/Assistant in Urology at the Massachusetts General Hospital/Harvard Medical School. In this capacity, he was primarily responsible for the surgical care and management of patients with complex urologic malignancies, specifically prostate and bladder cancer. He earned a BS with distinction in Anthropology, summa cum laude, from the University of Pennsylvania, an MBA from Harvard Business School, and an M.D. from the Yale School of Medicine. He received his general surgery, urology and urologic oncology fellowship training at the Massachusetts General Hospital/Harvard Medical School. He is board-certified in urology and licensed to practice medicine by the Commonwealth of Massachusetts Board of Registration in Medicine.
DENNIS H. GIESING, Ph.D.
Chief Scientific Officer
For over 30 years, Dr. Giesing has served in a variety of senior scientific and leadership roles within large pharmaceutical companies, with the last appointment being Senior Vice President, Lead Optimization at Aventis Pharmaceuticals, Inc. Prior to joining TARIS®, Dr. Giesing served as Chief Scientific Officer for Urigen Pharmaceuticals. Earlier pharma positions include Vice President, Global Drug Metabolism & Pharmacokinetics at Aventis, as well as other leadership roles at Hoechst Marion Roussel, Marion Merrell Dow and Marion Laboratories. He earned a BS in Chemistry and his PhD in Biochemical Pharmacology from the University of Missouri, Kansas City.
CHERYL LARRIVEE-ELKINS, MSChE
Chief Compliance Officer
Ms. Larrivee-Elkins brings to TARIS® over two decades of pharmaceutical industry experience, with expertise in product development, registration and manufacturing. Prior to joining TARIS®, Ms. Larrivee-Elkins filled several senior leadership roles at Alkermes, Inc., including Vice President of Research and Development and Vice President of Regulatory Affairs. Previously, Ms. Larrivee-Elkins was Director, Technical Regulatory Affairs at Sepracor, Inc., and held positions of increasing responsibility and leadership in pharmaceutical development and technical services during her eight-year tenure at AstraZeneca (formerly Astra USA). She earned her BS in Chemical Engineering from the Massachusetts Institute of Technology (MIT) and her MS in Chemical Engineering from the University of Wisconsin-Madison.
DIANE MARCOU, CPA
Chief Financial Officer
Ms. Marcou has provided financial and strategic advisory services to a number of venture-backed technology companies, including ByAllAccounts, Inc., Fluidnet Corporation, Radianse and T2 Biosystems. Prior to working as an independent financial consultant, she was Chief Financial Officer and Vice President of Finance and Administration for Incentive Systems (dba Centive), a privately held venture-funded software company, and Chief Financial Officer at Workgroup Technologies, a publicly traded software company with domestic and international operations. Ms. Marcou earned a BS in Business Administration from Boston College, and her CPA from PricewaterhouseCoopers, formerly Coopers & Lybrand.
Board of Directors
DENNIS A. AUSIELLO, M.D.
Massachusetts General Hospital
Dr. Ausiello is the Jackson Professor of Clinical Medicine at Harvard Medical School and the Physician-in-Chief of the Department of Medicine at Massachusetts General Hospital (MGH). Previously, Dr. Ausiello served as Chief of the MGH Renal Unit from 1983-1996 and oversaw its development into one of the most sought-after research and training programs in the world. He has made a substantial contribution to knowledge of epithelial biology in the areas of membrane protein trafficking, ion channel regulation and signal transduction, and has published over 100 papers, chapters and textbooks. Dr. Ausiello currently serves as the co-editor of Cecil's Textbook of Medicine (Elsevier), now in its 23rd edition. A nationally recognized leader in academic medicine, Dr. Ausiello was elected to the Institute of Medicine of the National Academy of Sciences in 1999 and the American Academy of Arts and Sciences in 2003.
AMIR NASHAT, Ph.D.
Dr. Nashat is a Managing Partner in Polaris’ Boston office. He joined Polaris in 2002 and focuses on investments in healthcare. Amir currently represents Polaris as a Director of AgBiome, aTyr Pharmaceuticals, Fate Therapeutics, Jnana Therapeutics, Marauder Therapeutics, Metacrine Therapeutics, Scholar Rock, Seletca Biosciences, Sofgren Medical and Syros Pharmaceuticals. Additionally, Amir has served as a Director of Adnexus Therapeutics (Bristol Myers Squibb), Athenix Corporation (Bayer), Avila Therapeutics (Celgene), Living Proof (Unilever), Pervasis Therapeutics (Shire Pharmaceuticals), Receptos (Celgene), and Sun Catalytix (Lockheed Martin). At Living Proof, Sun Catalytix, and Olivo Labs Amir served as the company’s initial CEO. Amir also serves on the Partners Innovation Fund, the Investment Advisory Committee for The Engine at MIT, and helped launch the MIT Sandbox Innovation Fund as its active president. He previously served on the Board of the New England Venture Capital Association. He has been named to the Forbes Midas List of “Top 100 Venture Capitalists.”
MICHAEL J. CIMA, Ph.D.
Massachusetts Institute of Technology
Dr. Cima is a cofounder and consultant to the TARIS® management team. He is a Professor of Materials Science and Engineering at the Massachusetts Institute of Technology (MIT) and an investigator at the Koch Institute for Integrative Cancer Research at MIT. Professor Cima is author or coauthor of over 190 peer-reviewed scientific publications and 45 patents, and is a recognized expert in the field of materials processing. Professor Cima is actively involved in materials and engineered systems aimed at improving human health, such as treatments for cancer, metabolic diseases, trauma and urological disorders. Professor Cima and collaborators are developing implantable devices for unprecedented control in the delivery of pharmaceuticals. He is also cofounder and a Director of MicroChips, Inc., and T2 Biosystems. Most recently, Professor Cima cofounded Entra Pharmaceuticals and TARIS®. Professor Cima earned a B.S. in Chemistry (Phi Beta Kappa) and a Ph.D. in chemical engineering, both from the University of California at Berkeley. He joined the MIT faculty in 1986 and was promoted to full Professor in 1995.
Mr. Finney has over 20 years of healthcare industry leadership experience spanning pharmaceutical, medical device and diagnostic segments. His extensive experience includes early stages of development through commercialized brands. He was most recently Vice President and Head of Corporate Development at Allergan, Inc.®, an international specialty pharmaceutical company operating in more than 100 countries worldwide. Previous to Allergan, Mr. Finney held commercial executive management roles at Prometheus Laboratories, Inc. (now NestleHealthScience), Amylin Pharmaceuticals, Inc. (now Bristol-Meyers Squibb), and Parke-Davis division of Warner-Lambert (now Pfizer). Mr. Finney earned an MBA from Pepperdine University and a B.A. from California State University Long Beach in Exercise Physiology.
Doug Cole joined Flagship Pioneering in 2001. He focuses on life science.
He holds an A.B. magna cum laude with high distinction in English from Dartmouth College, where he was a senior fellow and a member of Phi Beta Kappa, and an M.D. from the University of Pennsylvania School of Medicine, where he was a member of Alpha Omega Alpha. He obtained post-graduate training in medicine at the Johns Hopkins Hospital in Baltimore, MD and in neurology at the Massachusetts General Hospital in Boston, MA.
Before joining Flagship, Doug was instructor in neurology at Harvard Medical School and assistant in neurology at the Massachusetts General Hospital; medical director at Cytotherapeutics, in Providence, RI; and program executive at Vertex Pharmaceuticals, Inc., in Cambridge, MA.
At Flagship, Doug has co-founded Ensemble Therapeutics, Permeon Biologics, Moderna Therapeutics, Syros Pharmaceuticals (NASDAQ:SYRS), Sigilon Therapeutics, and Foghorn Therapeutics. He has led investments in Agios Pharmaceuticals (NASDAQ:AGIO), Alvine Pharmaceuticals, Avedro, CombinatoRx (NASDAQ:ZLCS), Concert Pharmaceuticals (NASDAQ:CNCE), Denali Therapeutics, Editas (NASDAQ:EDIT), Quanterix Corporation, Receptos (NASDAQ:RCPT), Seventh Sense Biosystems, Tetraphase Pharmaceuticals (NASDAQ:TTPH), and Torque. He currently serves on the board of directors of Denali, Editas, Foghorn, Quanterix, Sigilon, TARIS, and Torque. He formerly served on the board of directors of Avedro, AVEO Pharmaceuticals (NASDAQ: AVEO), CombinatoRx, Concert, CGI, KSQ, Moderna, Morphotek, Receptos, Resolvyx, Selecta (NASDAQ:SELB), Seventh Sense and Tetraphase.
Doug is a member of the scientific advisory board and the board of directors of the Spinal Muscular Atrophy Foundation.
ROBERT S. LANGER, Sc.D.
Massachusetts Institute of Technology
Dr. Langer is an Institute Professor at the Massachusetts Institute of Technology (MIT); there are 11 Institute Professors at MIT, and being an Institute Professor is the highest honor that can be awarded to a faculty member. He has written over 1,200 articles, which have been cited over 90,000 times; his h-index of 148 is the highest of any engineer in history. He has 815 issued and pending patents worldwide. His patents have licensed or sublicensed to over 250 companies. He served as Chairman of the FDA’s Science Board (its highest advisory board) from 1999-2002. His over 220 awards include both the United States National Medal of Science and the United States National Medal of Technology and Innovation, the Charles Stark Draper Prize (considered the engineering Nobel Prize), Albany Medical Center Prize, the Wolf Prize for Chemistry, the Millennium Technology Prize, the Priestley Medal (highest award of the American Chemical Society), the Gairdner Prize and the Lemelson-MIT prize, for being “one of history’s most prolific inventors in medicine.” He holds 20 honorary doctorates, including honorary degrees from Harvard and Yale. Langer is one of the very few individuals ever elected to the Institute of Medicine, the National Academy of Engineering, the National Academy of Sciences and the National Academy of Inventors.
PURNANAND D. SARMA, Ph.D.
Dr. Sarma comes to TARIS® with more than 20 years of pharmaceutical experience in large, medium and small companies. Most recently, he was General Manager and Vice President of Worldwide Drug Delivery Technologies of CIMA LABS, Inc., a wholly owned subsidiary of Cephalon (now Teva). Prior to Cephalon, Dr. Sarma served as Vice President of Pharmaceutical Development at Nektar Therapeutics (NASDAQ:NKTR), based in the San Francisco Bay area. Dr. Sarma started his career at SmithKline Beecham Pharmaceuticals, in the areas of formulation sciences and product development. He earned a Ph.D. in Pharmaceutics from the University of Minnesota and a B.S. in Pharmacy from Andhra University in Visakhapatnam, India.
RAJEEV SHAH (Board Observer)
RA Capital Management
Rajeev Shah is a Managing Director and Portfolio Manager at RA Capital Management. He is active in both public and private investments in companies developing drugs, medical devices, diagnostics, and research tools. Raj is active in the firm’s outreach efforts, speaking frequently both at industry events and in classrooms. Prior to joining RA Capital, Raj worked as a Senior Project Leader at Altus Pharmaceuticals, a spin-off company of Vertex Pharmaceuticals. At Altus, he assessed business processes and implemented system solutions for all science areas. Raj graduated from Cornell University, where he majored in Chemistry with a concentration in Economics.